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Hattori Y., Ishii H., Tahara S., Morita A., Ozawa H. Accurate assessment of estrogen receptor profiles in non-functioning pituitary adenomas using RT-digital PCR and immunohistochemistry. (2020) Life Science

Ishii H, Otsuka M, Kanaya M, Higo S, Hattori Y, Ozawa H.(2019) Applicability of Anti-Human Estrogen Receptor β Antibody PPZ0506 for the Immunodetection of Rodent Estrogen Receptor β Proteins. Int J Mol Sci.20(24).


Nishimura K, Yoshino K, Sanada K, Beppu H, Akiyama Y, Nishimura H, Tanaka K, Sonoda S, Ueno H, Yoshimura M, Maruyama T, Ozawa H, Ueta Y. Effect of oestrogen-dependent vasopressin on HPA axis in the median eminence of female rats. Science Report. 2019 Mar 26;9(1):5153. (2019)

Ishii H, Hattori Y, Ozawa H. Identification of a novel C-terminally truncated estrogen receptor α variant (ERαi34) with constitutive transactivation and estrogen receptor antagonist resistance. (2019) Mol Cell Endocrinol.

Kanaya M, Higo S, Ozawa H. (2019) Neurochemical Characterization of Neurons Expressing Estrogen Receptor β in the Hypothalamic Nuclei of Rats Using in Situ Hybridization and Immunofluorescence. Int J Mol Sci. 21(1).

Iwata K., Kunimura Y., Ozawa H.(2019) "Hypothalamic Kisspeptin Expression in Hyperandrogenic Female Rats and Aging Rats", ACTA HISTOCHEMICA ET CYTOCHEMICA, 52(5):85-91. Review

Ozaki S, Higo S, Iwata K, Saeki H,Ozawa H. (2019) Region-specific changes in brain kisspeptin receptor expression during estrogen depletion and the estrous cycle. Histochem Cell Biol.


Nakao K., Iwata K., Takeshita T., Ozawa H.(2018) "Expression of hypothalamic kisspeptin, neurokinin B, and dynorphin A neurons attenuates in female Zucker fatty rats", Neuroscience Letters, 665, 135-139.


Moeko Kanaya, Kinuyo Iwata, Hitoshi Ozawa, “Distinct dynorphin expression patterns with low- and high-dose estrogen treatment in the arcuate nucleus of female rats”, Biol Reprod, doi: 10.1093/biolre/iox131, 2017.

Ishii H, Hattori Y, Munetomo A, Watanabe H, Sakuma Y, Ozawa H. (2017) Characterization of rodent constitutively active estrogen receptor α variants and their constitutive transactivation mechanisms. General and Comparative Endocrinology 248:16-26.

Watanabe H, Ishii H, Takahashi K, Takai S, Ozawa H. (2017) Suitable reference gene selection for gene expression studies in knee osteoarthritis synovium using quantitative PCR analysis. Connective Tissue Research. 1-13.

Iwata K., Kunimura Y., Matsumoto K., Ozawa H.: Effect of Androgen on Kiss1 Expression and Luteinizing Hormone Release in Female Rats. Journal of Endocrinology. (2017)

Higo S., Iijima N., Ozawa H. "Characterization of Kiss1r (Gpr54)-expressing neurons in the arcuate nucleus of the female rat hypothalamus", Journal of Neuroendocrinology. (2017)

Tomori Y, Takumi K, Iijima N, Takai S, Ozawa H. "Kisspeptin expression is decreased in the arcuate nucleus of hypothyroid female rats with irregular estrus cycles", Neuroscience Research. (2017)

Kunimura Y, Iwata K, Ishigami A, Ozawa H. "Age-related alterations in hypothalamic kisspeptin, neurokinin B, and dynorphin neurons and in pulsatile LH release in female and male rats", Neurobiology of Aging 19 (2017) 30-38


Yujiro Hattori, Hirotaka Ishii, Arisa Munetomo, Hiroshi Watanabe, Akio Morita, Yasuo Sakuma, Hitoshi Ozawa, Human C-terminally truncated ERα variants resulting from the use of alternative exons in the ligand-binding domain. Molecular and Cellular Endocrinology, 425:111-22 (2016).

Iwata K.,Ikehara M.,Kunimura Y.,Ozawa H.: Interactions between Kisspeptin Neurons and Hypothalamic Tuberoinfundibular Dopaminergic Neurons in Aged Female Rats. ACTA HISTOCHEMICA ET CYTOCHEMICA. 49. 191-196. 2016

Nagamoto, S., Iijima, N., Ishii, H., Takumi, K., Higo, S., Aikawa, S., Anzai, M., Matsuo, I., Nakagawa, S., Takashima, N., Shigeyoshi, Y., Sakamoto, A., Ozawa, H. "Establishment of an in vitro cell line experimental system for the study of inhalational anesthetic mechanisms", Neurosci Lett 620 (2016) 163-168.

Murakawa, H., Iwata, K., Takeshita, T., Ozawa, H. "Immunoelectron microscopic observation of the subcellular localization of kisspeptin, neurokinin B and dynorphin A in KNDy neurons in the arcuate nucleus of the female rat", Neurosci Lett 612 (2016) 161-166.

Matsuo, I., Iijima, N., Takumi, K., Higo, S., Aikawa, S., Anzai, M., Ishii, H., Sakamoto, A., Ozawa, H. "Characterization of sevoflurane effects on Per2 expression using ex vivo bioluminescence imaging of the suprachiasmatic nucleus in transgenic rats", Neurosci Res 107 (2016) 30-37.

Li, S., Takumi, K., Iijima, N., Ozawa, H. "The increase in the number of spines on the gonadotropin-releasing hormone neuron across pubertal development in rats", Cell Tissue Res 364 (2016) 405-414.

Higo, S., Honda, S., Iijima, N., Ozawa, H. "Mapping of Kisspeptin Receptor mRNA in the Whole Rat Brain and its Co-Localisation with Oxytocin in the Paraventricular Nucleus", J Neuroendocrinol 28 (2016).


Takumi, K., Shimada, K., Iijima, N., Ozawa, H. "Maternal high-fat diet during lactation increases Kiss1 mRNA expression in the arcuate nucleus at weaning and advances puberty onset in female rats", Neurosci Res 100 (2015) 21-28.

Kunimura, Y., Iwata, K., Iijima, N., Kobayashi, M., Ozawa, H. "Effect of sex steroid hormones on the number of serotonergic neurons in rat dorsal raphe nucleus", Neurosci Lett 594 (2015) 127-132.

Higo, S., Aikawa, S., Iijima, N., Ozawa, H. "Rapid modulation of hypothalamic Kiss1 levels by the suckling stimulus in the lactating rat", J Endocrinol 227 (2015) 105-115.

Hattori, Y., Ishii, H., Morita, A., Sakuma, Y., Ozawa, H. "Characterization of the fundamental properties of the N-terminal truncation (Delta exon 1) variant of estrogen receptor alpha in the rat", Gene 571 (2015) 117-125.


Mori, K., Iijima, N., Higo, S., Aikawa, S., Matsuo, I., Takumi, K., Sakamoto, A., Ozawa, H. "Epigenetic suppression of mouse Per2 expression in the suprachiasmatic nucleus by the inhalational anesthetic, sevoflurane", PLoS One 9 (2014) e87319.

Iwata, K., Ozawa, H. "Expression of glucocorticoid receptor and coactivators in ependymal cells of male rats", Acta Histochem Cytochem 47 (2014) 165-174.


Anzai, M., Iijima, N., Higo, S., Takumi, K., Matsuo, I., Mori, K., Ohe, Y., Kadota, K., Akimoto, T., Sakamoto, A., Ozawa, H. "Direct and specific effect of sevoflurane anesthesia on rat Per2 expression in the suprachiasmatic nucleus", PLoS One 8 (2013) e59454.


Yang, C.Y., Matsuzaki, T., Iijima, N., Kajimura, N., Ozawa, H. "Morphofunctional changes of the astrocyte in rat hippocampus under different corticosteroid conditions", Med Mol Morphol 45 (2012) 206-213.

Yamazaki C., N.M., Sujino M., Kubo, A., Terashima T., Ozawa H., Shigeyoshi Y. "Application of layer-specific markers in the evaluation of abnormal cytoarchitecture in the olfactory bulb of prokineticin receptor 2 deficient mice", Acta Medica Kinki University 37 (2012) 35-43. [Link]

Takumi, K., Iijima, N., Iwata, K., Higo, S., Ozawa, H. "The effects of gonadal steroid manipulation on the expression of Kiss1 mRNA in rat arcuate nucleus during postnatal development", J Physiol Sci 62 (2012) 453-460.

Takumi, K., Iijima, N., Higo, S., Ozawa, H. "Immunohistochemical analysis of the colocalization of corticotropin-releasing hormone receptor and glucocorticoid receptor in kisspeptin neurons in the hypothalamus of female rats", Neurosci Lett 531 (2012) 40-45.

Sawai, N., Iijima, N., Takumi, K., Matsumoto, K., Ozawa, H. "Immunofluorescent histochemical and ultrastructural studies on the innervation of kisspeptin/neurokinin B neurons to tuberoinfundibular dopaminergic neurons in the arcuate nucleus of rats", Neurosci Res 74 (2012) 10-16.

Ozawa, H., Sawai, N., Iwata, K., Takumi, K., Iijima, N. "Regulation of tuberoinfundibular dopamine (TIDA) neurons by kisspeptin neurons", J Nippon Med Sch 79 (2012) 168-169.

Kadota, K., Iijima, N., Ohe-Hayashi, Y., Takumi, K., Higo, S., Sakamoto, A., Ozawa, H. "Time-dependent repression of mPer2 expression in the suprachiasmatic nucleus by inhalation anesthesia with sevoflurane", Neurosci Lett 528 (2012) 153-158.


小澤一史、託見健、澤井信彦、岩田衣世、中根亮、飯島典生. "Kisspeptin と性機能調節神経系-新しい間脳(視床下部)-下垂体-性腺系機能概念の構築", 顕微鏡 46 (2011) 111-118. [Link]

Tobari, Y., Iijima, N., Tsunekawa, K., Osugi, T., Haraguchi, S., Ubuka, T., Ukena, K., Okanoya, K., Tsutsui, K., Ozawa, H. "Identification, localisation and functional implication of 26RFa orthologue peptide in the brain of zebra finch (Taeniopygia guttata)", J Neuroendocrinol 23 (2011) 791-803.

Takumi, K., Iijima, N., Ozawa, H. "Developmental changes in the expression of kisspeptin mRNA in rat hypothalamus", J Mol Neurosci 43 (2011) 138-145.

Ohe, Y., Iijima, N., Kadota, K., Sakamoto, A., Ozawa, H. "The general anesthetic sevoflurane affects the expression of clock gene mPer2 accompanying the change of NAD+ level in the suprachiasmatic nucleus of mice", Neurosci Lett 490 (2011) 231-236.

Matsuzaki, T., Inahata, Y., Sawai, N., Yang, C.Y., Kobayashi, M., Takata, K., Ozawa, H. "Immunohistochemical Localization of the Water Channels AQP4 and AQP5 in the Rat Pituitary Gland", Acta Histochem Cytochem 44 (2011) 259-266.

Iijima, N., Takumi, K., Sawai, N., Ozawa, H. "An immunohistochemical study on the expressional dynamics of kisspeptin neurons relevant to GnRH neurons using a newly developed anti-kisspeptin antibody", J Mol Neurosci 43 (2011) 146-154.


松崎利行、小澤一史、高田邦昭, 腎臓と唾液腺における細胞膜水チャネル、アクアポリン, Vol. 44, 顕微鏡, 2009. 松崎利行. "細胞膜水チャネル、アクアポリン-腎臓を中心に- ", 日本医科大学医学界雑誌 5 (2009) 118-124. [Link]

小澤一史、松崎利行, 免疫電子顕微鏡の基礎と応用, 2009, 25−34 pp.

Oki, K., Murakami, M., Tanuma, K., Ogawa, R., Ozawa, H., Hyakusoku, H. "Anatomical study of pectoral intercostal perforators and clinical study of the pectoral intercostal perforator flap for hand reconstruction", Plast Reconstr Surg 123 (2009) 1789-1800.

Okabe, T., Sato, C., Matsumoto, K., Ozawa, H., Sakamoto, A. "Electroconvulsive stimulation (ECS) increases the expression of neuropeptide Y (NPY) in rat brains in a model of neuropathic pain: a quantitative real-time polymerase chain reaction (RT-PCR) study", Pain Med 10 (2009) 1460-1467.

Matsuzaki, T., Hata, H., Ozawa, H., Takata, K. "Immunohistochemical localization of the aquaporins AQP1, AQP3, AQP4, and AQP5 in the mouse respiratory system", Acta Histochem Cytochem 42 (2009) 159-169.


小澤一史. "ストレス、摂食、性の制御機構に関する中枢神経ネットワーク", 日本医科大学医学会雑誌 4 (2008) 25-31. [Link]

Yoshii, T., Sakamoto, H., Kawasaki, M., Ozawa, H., Ueta, Y., Onaka, T., Fukui, K., Kawata, M. "The single-prolonged stress paradigm alters both the morphology and stress response of magnocellular vasopressin neurons", Neuroscience 156 (2008) 466-474.

Yang, C.Y., Xue, H.G., Tanuma, K., Ozawa, H. "Variations of the bilateral testicular veins: embryological and clinical considerations", Surg Radiol Anat 30 (2008) 53-55.

Xue, H.G., Yang, C.Y., Yamamoto, N. "Afferent sources to the inferior olive and distribution of the olivocerebellar climbing fibers in cyprinids", J Comp Neurol 507 (2008) 1409-1427.

Nagano, M., Ozawa, H., Suzuki, H. "Prenatal dexamethasone exposure affects anxiety-like behaviour and neuroendocrine systems in an age-dependent manner", Neurosci Res 60 (2008) 364-371.

Aoki, S., Tanuma, K., Iwakiri, I., Mizuno, H., Ogawa, R., Ozawa, H., Hyakusoku, H. "Clinical and vascular anatomical study of distally based sural flap", Ann Plast Surg 61 (2008) 73-78.

Akimoto, T., Nakama, K., Katsuta, Y., Zhang, X.J., Ohsuga, M., Ishizaki, M., Sawai, N., Ozawa, H. "Characterization of a novel congenic strain of diabetic fatty (WBN/Kob-Lepr(fa)) rat", Biochem Biophys Res Commun 366 (2008) 556-562.


小澤一史: (分担) (大野忠雄, 黒沢美重子, 高橋研一, 細谷安彦, 他共訳). "トートラ人体の構造と機能", 第2版 (2007).

Yang, C.Y., Xue, H.G., Yoshimoto, M., Ito, H., Yamamoto, N., Ozawa, H. "Fiber connections of the corpus glomerulosum pars rotunda, with special reference to efferent projection pattern to the inferior lobe in a percomorph teleost, tilapia (Oreochromis niloticus)", J Comp Neurol 501 (2007) 582-607.

Yamamoto, N., Ishikawa, Y., Yoshimoto, M., Xue, H.G., Bahaxar, N., Sawai, N., Yang, C.Y., Ozawa, H., Ito, H. "A new interpretation on the homology of the teleostean telencephalon based on hodology and a new eversion model", Brain Behav Evol 69 (2007) 96-104.

Xue, H.G., Yang, C.Y., Yamamoto, N., Ozawa, H. "Fiber connections of the periventricular pretectal nucleus in a teleost, tilapia (Oreochromis niloticus)", Neurosci Res 57 (2007) 184-193.

Xue, H.G., Yang, C.Y., Asakawa, M., Tanuma, K., Ozawa, H. "Duplication of the inferior vena cava associated with other variations", Anat Sci Int 82 (2007) 121-125.

Shibata, M., Fujihara, H., Suzuki, H., Ozawa, H., Kawata, M., Dayanithi, G., Murphy, D., Ueta, Y. "Physiological studies of stress responses in the hypothalamus of vasopressin-enhanced green fluorescent protein transgenic rat", J Neuroendocrinol 19 (2007) 285-292.

Nagae, M., Ikeda, T., Mikami, Y., Hase, H., Ozawa, H., Matsuda, K., Sakamoto, H., Tabata, Y., Kawata, M., Kubo, T. "Intervertebral disc regeneration using platelet-rich plasma and biodegradable gelatin hydrogel microspheres", Tissue Eng 13 (2007) 147-158.

Ito, H., Ishikawa, Y., Yoshimoto, M., Yamamoto, N. "Diversity of brain morphology in teleosts: brain and ecological niche", Brain Behav Evol 69 (2007) 76-86.

Ishikawa, Y., Yamamoto, N., Yoshimoto, M., Yasuda, T., Maruyama, K., Kage, T., Takeda, H., Ito, H. "Developmental origin of diencephalic sensory relay nuclei in teleosts", Brain Behav Evol 69 (2007) 87-95.

Han, F., Ozawa, H., Matsuda, K.I., Lu, H., De Kloet, E.R., Kawata, M. "Changes in the expression of corticotrophin-releasing hormone, mineralocorticoid receptor and glucocorticoid receptor mRNAs in the hypothalamic paraventricular nucleus induced by fornix transection and adrenalectomy", J Neuroendocrinol 19 (2007) 229-238.


田沼久美子, 益田律子, 三枝英人(監修). "しくみと病気がわかるからだの事典" (2006).

小澤一史,千田隆夫,高田邦昭監訳. "トートラ解剖学" (2006).

Xue, H.G., Yang, C.Y., Ito, H., Yamamoto, N., Ozawa, H. "Primary and secondary sensory trigeminal projections in a cyprinid teleost, carp (Cyprinus carpio)", J Comp Neurol 499 (2006) 626-644.

Xue, H.G., Yamamoto, N., Yang, C.Y., Kerem, G., Yoshimoto, M., Sawai, N., Ito, H., Ozawa, H. "Projections of the sensory trigeminal nucleus in a percomorph teleost, tilapia (Oreochromis niloticus)", J Comp Neurol 495 (2006) 279-298.

Saigusa, H., Tanuma, K., Yamashita, K., Saigusa, M., Niimi, S. "Nerve fiber analysis for the lingual nerve of the human adult subjects", Surg Radiol Anat 28 (2006) 59-65.

Kokawa, T., Saigusa, H., Aino, I., Matsuoka, C., Nakamura, T., Tanuma, K., Yamashita, K., Niimi, S. "Physiological studies of retrusive movements of the human tongue", J Voice 20 (2006) 414-422.

Kinoshita, M., Ito, E., Urano, A., Ito, H., Yamamoto, N. "Periventricular efferent neurons in the optic tectum of rainbow trout", J Comp Neurol 499 (2006) 546-564.


小澤一史, 河田光博. "視床下部領域における摂食制御神経系ネットワーク", 京都府立医科大学雑誌 114 (2005) 337-346.

Yamamoto, N., Ito, H. "Fiber connections of the anterior preglomerular nucleus in cyprinids with notes on telencephalic connections of the preglomerular complex", J Comp Neurol 491 (2005) 212-233.

Yamamoto, N., Ito, H. "Fiber connections of the central nucleus of semicircular torus in cyprinids", J Comp Neurol 491 (2005) 186-211.

Xue, H.G., Yang, C.Y., Yamamoto, N., Ito, H., Ozawa, H. "An indirect trigeminocerebellar pathway through the nucleus lateralis valvulae in a perciform teleost, Oreochromis niloticus", Neurosci Lett 390 (2005) 104-108.

Xue, H.G., Yang, C.Y., Ishida, S., Ishizaka, K., Ishihara, A., Ishida, A., Tanuma, K. "Duplicate testicular veins accompanied by anomalies of the testicular arteries", Ann Anat 187 (2005) 393-398.

Tanaka, M., Iijima, N., Miyamoto, Y., Fukusumi, S., Itoh, Y., Ozawa, H., Ibata, Y. "Neurons expressing relaxin 3/INSL 7 in the nucleus incertus respond to stress", Eur J Neurosci 21 (2005) 1659-1670.

Sano, K., Hyakusoku, H., Tanuma, K. "Clinical reappraisal of the segmental pectoralis major turn-over flap for coverage of the local mediastinal wound", Scand J Plast Reconstr Surg Hand Surg 39 (2005) 290-294.

Ozawa, H. "Steroid Hormones, their receptors and neuroendocrine system", J Nippon Med Sch 72 (2005) 316-325.

Kerem, G., Yoshimoto, M., Yamamoto, N., Yang, C.Y., Xue, H.G., Ito, H. "Somatotopic organization of the trigeminal ganglion cells in a cichlid fish, Oreochromis (Tilapia) niloticus", Brain Behav Evol 65 (2005) 109-126.

Kawate, T., Sakamoto, H., Yang, C., Li, Y., Shimada, O., Atsumi, S. "Immunohistochemical study of delta and mu opioid receptors on synaptic glomeruli with substance P-positive central terminals in chicken dorsal horn", Neurosci Res 53 (2005) 279-287.

Han, F., Ozawa, H., Matsuda, K., Nishi, M., Kawata, M. "Colocalization of mineralocorticoid receptor and glucocorticoid receptor in the hippocampus and hypothalamus", Neurosci Res 51 (2005) 371-381.