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美辺 詩織Shiori Minabe
日本学術振興会特別研究員




研究テーマ

肥満が妊孕性低下を引き起こす神経内分泌メカニズムの解明
胎児期のストレスにより思春期が早発する神経内分泌メカニズムの解明


略歴

平成 18年4月 名古屋大学農学部資源生物科学科卒業
平成 24年3月 名古屋大学大学院生命農学研究科博士課程前期課程生命技術科学専攻修了
平成 24年4月 日本学術振興会特別研究員 (DC1) 平成24年度-26年度
平成 27年3月 名古屋大学大学院生命農学研究科博士課程後期課程生命技術科学専攻修了
平成 27年4月 農業・食品産業技術総合研究機構 畜産草地研究所 契約研究員
平成 28年4月 東京大学大学院 農学生命科学研究科獣医繁殖育種研究室 特任研究員
平成 29年4月 東京大学大学院 農学生命科学研究科獣医繁殖育種研究室 特任助教
平成 30年4月 日本医科大学大学院 医学研究科 解剖学・神経生物学分野 ポストドクター
令和 2年4月 日本学術振興会特別研究員(RPD)


所属学会

日本繁殖生物学会、日本畜産学会、日本生殖内分泌学会、日本神経内分泌学会、Endocrine Society


受賞歴

2018年3月「the Eugenia Rosemberg Abstract Travel Award」受賞、ENDO2018
2017年9月「学術奨励賞」受賞、第22回生殖内分泌学会学術集会
2014年8月「最優秀発表賞」受賞、第29回日本下垂体研究会


研究手法・テクニック

ラット・マウスやウシにおける無麻酔・無拘束下での頻回採血、げっ歯類を用いた薬物投与のための脳手術、in situ hybridization、免疫組織化学、ホルモン測定(RIA、EIA)、in vitro細胞内カルシウム測定、single-cell RT-PCRなど


論文

S. Minabe., K. Iwata, H. Tsuchida, H. Tsukamura, H. Ozawa, Effect of diet-induced obesity on kisspeptin-neurokinin B-dynorphin A neurons in the arcuate nucleus and luteinizing hormone secretion in sex hormone-primed male and female rats, Peptides (2021) 170546.

T.E. Wang, S. Minabe., F. Matsuda, S.H. Li, H. Tsukamura, K.I. Maeda, L. Smith, L. O'Hara, B.M. Gadella, P.S. Tsai, Testosterone regulation on quiescin sulfhydryl oxidase 2 synthesis in the epididymis, Reproduction (2021).

R. Tatebayashi, S. Nakamura, S. Minabe., T. Furusawa, R. Abe, M. Kajisa, Y. Morita, S. Ohkura, K. Kimura, S. Matsuyama, Gene-expression profile and postpartum transition of bovine endometrial side population cells, Biol Reprod (2021).

S. Nakamura, K. Noda, M. Miwa, S. Minabe., T. Hagiwara, A. Hirasawa, S. Matsuyama, R. Moriyama, Colocalization of GPR120 and anterior pituitary hormone-producing cells in female Japanese Black cattle, J Reprod Dev 66(2) (2020) 135-141.

Minabe S., Nakamura S, Fukushima E, Sato M, Ikegami K, Goto T, Sanbo M, Hirabayashi M, Tomikawa J, Imamura T, Inoue N, Uenoyama Y, Tsukamura H, Maeda KI, and Matsuda F. (2020) Inducible Kiss1 knockdown in the hypothalamic arcuate nucleus suppressed pulsatile secretion of luteinizing hormone in male mice. Journal of Reproduction and Development.

Ieda N, Assadullah, Minabe S., Ikegami K, Watanabe Y, Sugimoto Y, Sugimoto A, Kawai N, Ishii H, Inoue N, Uenoyama Y, Tsukamura H. (2020) GnRH(1-5), a metabolite of gonadotropin-releasing hormone, enhances luteinizing hormone release via activation of kisspeptin neurons in female rats. Endocr J. 2020

Minabe S., Sato M., Inoue M., Watanabe Y., Nagata F., Matsuda F., Uenoyama Y., Ozawa H., Tsukamura H. : Neonatal estrogen causes irreversible male infertility via specific suppressive action on hypothalamic Kiss1 neurons. Endocrinology, 160, 1223-1233.

Nakamura S, Noda K, Miwa M, Minabe S. Hagiwara T, Hirasawa A, Matsuyama S, Moriyama R. Colocalization of GPR120 and anterior pituitary hormone-producing cells in female Japanese Black cattle. (2019) Journal of Reproduction and Development.

Deura C, Minabe S., Ikegami K, Inoue N, Uenoyama Y, Maeda KI, Tsukamura H. Morphological analysis for neuronal pathway from the hindbrain ependymocytes to the hypothalamic kisspeptin neurons. (2019) Journal of Reproduction and Development, 65:129-137

Wang, T.E., Li, S.H., Minabe, S., Anderson, A.L., Dun, M.D., Maeda, K., Matsuda, F., Chang, H.W., Nixon, B., Tsai, P.J. (2018) Mouse quiescin sulfhydryl oxidases exhibit distinct epididymal luminal distribution with Segment-Specific sperm surface associations. Biology of Reproduction 99, 1022-1033

Ikeda, M., Matsuyama, S., Akagi, S., Ohkoshi, K., Nakamura, S., Minabe, S., Kimura, K., Hosoe, M. (2017) Correction of a Disease Mutation using CRISPR/Cas9-assisted Genome Editing in Japanese Black Cattle. Scientific Reports 7, 17827

Minabe, S., Ieda, N., Watanabe, Y., Inoue, N., Uenoyama, Y., Maeda, K., Tsukamura, H. (2017) Long-term neonatal estrogen exposure causes irreversible inhibition of LH pulses by suppressing arcuate kisspeptin expression via estrogen receptors α and β in female rodents. Endocrinology 158, 2918-2929.

Ikegami, K., Minabe, S., Ieda, N., Goto, T., Sugimoto, A., Nakamura, S., Inoue, N., Oishi, S., Maturana, AD., Sanbo, M., Hirabayashi, M., Maeda, K., Tsukamura, H., Uenoyama, Y. (2017) Evidence of involvement of neurone-glia/neurone-neurone communications via gap junctions in synchronised activity of KNDy neurones. Journal of Neuroendocrinology 29.

Uenoyama, Y., Tomikawa, J., Inoue, N., Goto, T., Minabe, S., Ieda, N., Nakamura, S., Watanabe, Y., Ikegami, K., Matsuda, F., Ohkura, S., Maeda, K., Tsukamura, H. (2016) Molecular and Epigenetic Mechanism Regulating Hypothalamic Kiss1 Gene Expression in Mammals. Neuroendocrinology 103, 640-649.

Ojima-Kato, T., Hashimura, D., Kojima, T., Minabe, S., Nakano, H. (2015) In vitro generation of rabbit anti-Listeria monocytogenes monoclonal antibody using single cell based RT-PCR linked cell-free expression systems. Journal of Immunological Methods 427, 58-65.

Minabe, S., Deura, C., Ikegami, K., Goto, T., Sanbo, M., Hirabayashi, M., Inoue, N., Uenoyama, Y., Maeda, K., Tsukamura, H. (2015) Pharmacological and morphological evidence of AMPK-mediated energy sensing in the lower brain stem ependymocytes to control reproduction in female rodents. Endocrinology 156, 2278-2287.

Goto, T., Tomikawa, J., Ikegami, K., Minabe, S., Abe, H., Fukanuma, T., Imamura, T., Takase, K., Sanbo, M., Tomita, K., Hirabayashi, M., Maeda, K., Tsukamura, H., Uenoyama, Y. (2015) Identification of hypothalamic arcuate nucleus-specific enhancer region of kiss1 gene in mice. Molecular Endocrinology 29, 121-129.

Uenoyama, Y., Nakamura, S., Hayakawa, Y., Ikegami, K., Watanabe, Y., Deura, C., Minabe, S., Tomikawa, J., Goto, T., Ieda, N., Inoue, N., Sanbo, M., Tamura, C., Hirabayashi, M., Maeda, K., Tsukamura, H. (2015) Lack of pulse and surge modes and glutamatergic stimulation of LH release in Kiss1 knockout rats. Journal of Neuroendocrinology 27, 187-197.

Ieda, N., Uenoyama, Y., Tajima, Y., Nakata, T., Kano, M., Naniwa, Y., Watanabe, Y., Minabe, S., Tomikawa, J., Inoue, N., Matsuda. F., Ohkura, S., Maeda, K., Tsukamura, H. (2014) KISS1 gene expression in the developing brain of female pigs in pre- and peripubertal periods. Journal of Reproduction and Development 60, 312-316.

Nakahara, T., Uenoyama, Y., Iwase, A., Oishi, S., Nakamura, S., Minabe, S., Watanabe, Y., Deura, C., Noguchi, T., Fujii, N., Kikkawa, F., Maeda, K., Tsukamura, H. (2013) Chronic peripheral administration of kappa-opioid receptor antagonist advances puberty onset associated with acceleration of pulsatile luteinizing hormone secretion in female rats. Journal of Reproduction and Development 59, 479-484.

Sakakibara, M., Uenoyama, Y., Minabe, S., Watanabe, Y., Deura, C., Nakamura, S., Suzuki, G., Maeda, K., Tsukamura, H. (2013) Microarray analysis of perinatal-estrogen-induced changes in gene expression related to brain sexual differentiation in mice. PLoS One 8, e79437.

Mostari, M. P., Ieda, N., Deura, C., Minabe, S., Yamada, S., Uenoyama, Y., Maeda, K., Tsukamura, H. (2012) Dynorphin-kappa opioid receptor signaling partly mediates estrogen negative feedback effect on LH pulses in female rats. Journal of Reproduction and Development 59, 266-272.

Yamada, S., Uenoyama, Y., Deura, C., Minabe, S., Naniwa, Y., Iwata, K., Kawata, M., Maeda, K., Tsukamura, H. (2012) Oestrogen-dependent suppression of pulsatile luteinising hormone secretion and kiss1 mRNA expression in the arcuate nucleus during late lactation in rats. Journal of Neuroendocrinology 24,1234-1242.

Sakakibara, M., Deura, C., Minabe, S., Iwata, Y., Uenoyama, Y., Maeda, K., Tsukamura, H. (2012) Different critical perinatal periods and hypothalamic sites of oestradiol action in the defeminisation of luteinising hormone surge and lordosis capacity in the rat. Journal of Neuroendocrinology 25, 251-259.

Tomikawa, J., Uenoyama, Y., Ozawa, M., Fukanuma, T., Takase, K., Goto. T., Abe, H., Ieda, N., Minabe, S., Deura, C., Inoue, N., Sanbo, M., Tomita, K., Hirabayashi, M., Tanaka, S., Imamura, T., Okamura, H., Maeda, K., Tsukamura, H. (2012) Epigenetic regulation of Kiss1 gene expression mediating estrogen-positive feedback action in the mouse brain. Proceedings of the National Academy of Sciences of the United States of America 109, E1294-1301.

Minabe, S., Uenoyama, Y., Tsukamura, H., Maeda, K. (2011) Analysis of pulsatile and surge-like luteinizing hormone secretion with frequent blood sampling in female mice. Journal of Reproduction and Development 57, 660-664.